Dissecting Oct3/4-Regulated Gene Networks in Embryonic Stem Cells by Expression Profiling
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منابع مشابه
Dissecting Oct3/4-Regulated Gene Networks in Embryonic Stem Cells by Expression Profiling
POU transcription factor Pou5f1 (Oct3/4) is required to maintain ES cells in an undifferentiated state. Here we show that global expression profiling of Oct3/4-manipulated ES cells delineates the downstream target genes of Oct3/4. Combined with data from genome-wide chromatin-immunoprecipitation (ChIP) assays, this analysis identifies not only primary downstream targets of Oct3/4, but also seco...
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Background and purpose: Spermatogenesis is a well-organized process that is influenced by a variety of factors. Alkaline phosphatase, and Gfra1, Lin28, and Sall4 genes are among the key players in this interconnected process. This study aimed to investigate the expression levels of Gfra1, Lin28, and Sall4 genes in embryonic, spermatogonial, and embryonic stem-like (ES-like) cells in mice. Mate...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2006
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0000026